1036 Results for "

Platycodon grandiflorus (Jacq.) A. DC.

" in MedChemExpress (MCE) Product Catalog:
Products (1036)

1036 Results for "Platycodon grandiflorus (Jacq.) A. DC." in MCE Product Catalog:

18
SGI-1027
SGI-1027
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18 Publications Verification
Art. -Nr.: HY-13962
CAS. Nr.: 1020149-73-8
Reinheit:  99.77%
Target:  

DNA Methyltransferase Apoptosis

Forschungsgebiete:  

Cancer

SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
11
ACBI1
ACBI1
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11 Cited Publications
Art. -Nr.: HY-128359
CAS. Nr.: 2375564-55-7
Reinheit:  99.92%
Target:  

PROTACs SWI/SNF Complex Apoptosis

Forschungsgebiete:  

Cancer

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis .
11
Ligustrazine hydrochloride
Ligustrazine hydrochloride
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11 Cited Publications
Art. -Nr.: HY-N0935
CAS. Nr.: 76494-51-4
Synonyms: Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Category:  

Alkaloids Other Alkaloids Other Diseases Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine hydrochloride is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine hydrochloride reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine hydrochloride possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
9
Phen-DC3 Trifluoromethanesulfonate
Phen-DC3 Trifluoromethanesulfonate
0 Images
9 Cited Publications
Art. -Nr.: HY-15594A
CAS. Nr.: 929895-45-4
Reinheit:  98.99%
Synonyms: Phen-DC3 Triflate
Target:  

G-quadruplex

Forschungsgebiete:  

Cancer

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
8
Platycodin D
Platycodin D
0 Images
8 Cited Publications
Art. -Nr.: HY-N1411
CAS. Nr.: 58479-68-8
Category:  

Triterpenes Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields

Target:  

AMPK Wnt

Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .
8
LY 345899
LY 345899
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8 Cited Publications
Art. -Nr.: HY-101943
CAS. Nr.: 10538-99-5
Reinheit:  ≥98.0%
Target:  

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Forschungsgebiete:  

Cancer

LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1 .
8
PROTAC FAK degrader 1
PROTAC FAK degrader 1
0 Images
8 Cited Publications
Art. -Nr.: HY-119932
CAS. Nr.: 2301916-69-6
Reinheit:  99.25%
Target:  

PROTACs FAK Akt

Forschungsgebiete:  

Cancer

PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor .
6
DC661
DC661
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6 Cited Publications
Art. -Nr.: HY-111621
CAS. Nr.: 1872387-43-3
Reinheit:  99.53%
Target:  

Autophagy Apoptosis

Forschungsgebiete:  

Cancer

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity .
6
DC_AC50
DC_AC50
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6 Cited Publications
Art. -Nr.: HY-107636
CAS. Nr.: 497061-48-0
Reinheit:  99.97%
Target:  

Apoptosis

Forschungsgebiete:  

Cancer

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .
6
Vepdegestrant
Vepdegestrant
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6 Cited Publications
Art. -Nr.: HY-138642
CAS. Nr.: 2229711-68-4
Reinheit:  99.60%
Synonyms: ARV-471
Target:  

PROTACs Estrogen Receptor/ERR

Forschungsgebiete:  

Cancer

Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
5
MT-802
MT-802
0 Images
5 Cited Publications
Art. -Nr.: HY-122562
CAS. Nr.: 2231744-29-7
Reinheit:  98.35%
Target:  

PROTACs Btk

Forschungsgebiete:  

Cancer

MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK (DC50 = 14.6 nM) and BTK mutants including E41K, C481S (DC50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib (HY-10997)-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand (HY-150885), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-141371), E3 ligase ligand-linker conjugate (HY-176340)) .
4
DC-Y13-27
DC-Y13-27
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4 Cited Publications
Art. -Nr.: HY-154919
Reinheit:  99.52%
Target:  

YTHDF FOXO MMP Pyroptosis Interleukin Related

Forschungsgebiete:  

Endocrinology Cancer

DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (KD: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .
4
Naringin Dihydrochalcone
Naringin Dihydrochalcone
0 Images
4 Cited Publications
Art. -Nr.: HY-N0119
CAS. Nr.: 18916-17-1
Synonyms: Naringin DC
Category:  

other families Flavonoids Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Sweeteners Cancer Food Research

Target:  

NF-κB

Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
4
Neohesperidin dihydrochalcone
Neohesperidin dihydrochalcone
0 Images
4 Cited Publications
Art. -Nr.: HY-N0154
CAS. Nr.: 20702-77-6
Synonyms: Neohesperidin DC; NHDC
Category:  

other families Flavonoids Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Inflammation/Immunology Sweeteners Food Research

Target:  

Reactive Oxygen Species (ROS)

Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.
4
dBET57
dBET57
0 Images
4 Cited Publications
Art. -Nr.: HY-123844
CAS. Nr.: 1883863-52-2
Reinheit:  99.94%
Target:  

PROTACs Epigenetic Reader Domain Apoptosis

Forschungsgebiete:  

Cancer

dBET57 is an effective and selective BRD4BD1 degrader based on PROTAC technology, with the ability to induce cell apoptosis and anti-tumor activity. dBET57 mediates the recruitment of the E3 ubiquitin ligase CRL4 Cereblon, showing a DC50/5h value of 500 nM for BRD4BD1 .
4
Nitidine chloride
Nitidine chloride
0 Images
4 Cited Publications
Art. -Nr.: HY-N0498
CAS. Nr.: 13063-04-2
Category:  

Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB

Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .
3
DC260126
DC260126
0 Images
3 Cited Publications
Art. -Nr.: HY-101906
CAS. Nr.: 346692-04-4
Reinheit:  99.57%
Target:  

Free Fatty Acid Receptor Apoptosis

Forschungsgebiete:  

Metabolic Disease

DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca 2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively) . DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .
3
Deapioplatycodin D
Deapioplatycodin D
0 Images
3 Cited Publications
Art. -Nr.: HY-N0588
CAS. Nr.: 78763-58-3
Category:  

Infection Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields

Target:  

HCV

Deapioplatycodin D is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity .
3
Platycodin D2
Platycodin D2
0 Images
3 Cited Publications
Art. -Nr.: HY-N4087
CAS. Nr.: 66663-90-9
Category:  

Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer

Target:  

Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)

Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .
3
ZXH-3-26
ZXH-3-26
0 Images
3 Cited Publications
Art. -Nr.: HY-122826
CAS. Nr.: 2243076-67-5
Reinheit:  98.90%
Target:  

PROTACs Epigenetic Reader Domain

Forschungsgebiete:  

Cancer

ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM .
Assay Types